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Both drugs are leukotriene receptor antagonists (LTRAs) and both were approved more than a decade ago as alternatives to "preventer" inhalers. But they are not as widely used and some studies have found them to be less effective for asthma control in patients with mild persistent asthma. In one, patients with chronic asthma were treated daily with an LTRA or an inhaled steroid to prevent asthma attacks. In another an LTRA Burberry Large Leather Duffle Bag

"The drug licensing trials excluded the elderly, smokers, those who were depressed, diabetics and a long list of other conditions that people actually have," he says. "The intent was to determine how well the drugs work in the best of circumstances, but that doesn't necessarily tell you how real people do on particular treatments."

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Prada Quilted Double Large Leather Top Handle Bag

May 4, 2011 The drugs Accolate proved to be just as effective as steroid inhalers for the prevention of asthma symptoms with better patient compliance in two new studies published in this week's New England Journal of Medicine.

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Merck issued a statement saying that the company is pleased that independent researchers are showing continued interest in evaluating the use of leukotriene receptor antagonists, including Singulair, as an important option for treating asthma in appropriate patients.

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All the asthma patients continued to use short acting "rescue" inhalers when needed to open constricted airways and help them breathe when asthma attacks occurred. tells WebMD.

"These drugs are an acceptable alternative to the traditional first line preventive treatments," he tells WebMD. "In general practice, where these drugs are most often prescribed, there may not be enough time to teach patients how to properly use inhalers.

InhalersIn both trials, the LTRAs appeared to work as well as the inhaled treatments for preventing asthma symptoms over two years of follow up, and in both trials, patients in the LTRA sections of the study proved to be Prada Quilted Double Large Leather Top Handle Bag more compliant with the treatments.

"Patients should talk to their doctors to determine the treatment that might work best for them," he says.

Merck Co., which makes Singulair, and AstraZeneca, which makes Accolate, provided some funding, but Musgrave says the companies were not involved with the design or execution of the study or the interpretation of the results.

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The oral drugs have traditionally been more expensive than inhaled prevention treatments, but Dahlen says this should soon change as generic versions of both Singular and Accolate enter the market.

with an inhaled steroid.

"We think this alternative approach works in the real world setting primarily because it is easier to take a pill once or twice a day than to use an inhaler," asthma researcher Sven Erik Dahlen, MD, PhD, of Stockholm, Sweden's Karolinska Institute and colleagues write in an editorial.

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Pills as Effective as Inhalers for Asthma

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or an inhaled long acting bronchodilator (LABA) was added to treatment Burberry Bags Price In London

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Prada Quilted Double Large Leather Top Handle Bag

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Rates of treatment adherence were 65% and 74% among patients who took the LTRA pills, compared to 41% and 46% among patients treated with the preventive inhaled steroids.

Musgrave says even though the oral drugs appear to be as effective for the prevention of asthma symptoms, they may not be the best choice for every patient.

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